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Rob Howard rocked the boat last week in calling for the deprecation of WordPress multisite in the latest MasterWP newsletter. He argued that “the brave and noble add-on is no longer necessary or valuable to developers.” The responses via Twitter were swift and in disagreement.
Before WordPress 3.0, multisite was an entirely separate system called WPMU (WordPress MultiUser). It was a mess to set up, and one of the best things to ever happen to it was that it was rolled into core WordPress. It became a first-class citizen in the WordPress world, and its setup is now simple enough that nearly anyone can get a network up and running in no time.
I have not used multisite much in my career in the WordPress space. My primary use case has been for setting up theme and plugin demos. These are sites that I do not intend to touch much outside of their initial setup. Multisite always makes it easy to manage theme and plugin updates from the network admin.